Tragacanth and xanthan gum natural polymers for formulation of clotrimazole mucoadhesive gel
Clotrimazole is an antifungal agent, widely used in vulvovaginal and oropharyngeal candidiasis.Currently available clotrimazole (especially vaginal) dosage forms, have some limitations, including: leakage, messiness and low residence time, which leads to poor patient compliance.Therefore, in this study, a clotrimazole mucoadhesive gel has been deve